PHARMACOLOGICAL STUDIES ON 8-[(1, 4-BENZODIOXAN-2-YL) METHYL]-3-OXO-1-THIA-4, 8-DIAZASPIRO-[4, 5]-DECANE MALEATE
نویسندگان
چکیده
منابع مشابه
Pharmacological studies on 8-[(1,4-benzodioxan-2-yl) methyl]-3-oxo-1-thia-4,8-diazaspiro-[4,5]-decane maleate.
Studies have been so far made on the benzodioxane derivatives as a cardiovascular drug which were reported as a peripheral vasodilator, or as a hypotensive agent by Schaper et al. (1) and Green et al. (2). 8-[(1, 4-benzodioxan-2-yl) methyl]-3-oxo-l-thia-4, 8-dia zaspiro-[4, 5]-decane maleate (Y-3506) was found desirable as a peripheral vasodilator with low toxicity among the new derivatives syn...
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The title mol-ecule, C(22)H(17)BrN(2)O(4)S, has a twisted U shape, the dihedral angle between the quinazolin-4-one and bromo-benzene ring systems being 46.25 (8)°. In order to avoid steric clashes with adjacent substituents on the quinazolin-4-one ring, the N-bound tolyl group occupies an orthogonal position [dihedral angle = 89.59 (8)°]. In the crystal, mol-ecules are connected into a three-di...
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New pyrimido [4, 5-e] [1, 3, 4]thia- diazin-7-yl] hydrazines were synthesized via the cyclocondensation of alkyl-2-phenylhydrazinecarbodithioates as a binucleophile with 5-bromo-2,4-dichloro-6-methylpyrimidine as a bielectrophile , and replacement of C-7 chloro atom by hydrazine in ethanol as the solvent . This method has advantages over methods currently described in the literature for the con...
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A series of (5-nitrofuran-2-yl)-1, 3, 4-thiadiazole-2-yl derivatives 6a–6e have been synthesized and screened for in vitro anti-leishmanial activity against the promastigote form of L. major. The structure of Schiff bases were confirmed by 1H NMR, IR. Screening results indicate that all of the designed and synthesized final compounds (6a-6e) significantly reduced the viability of promastigotes ...
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ژورنال
عنوان ژورنال: The Japanese Journal of Pharmacology
سال: 1971
ISSN: 0021-5198,1347-3506
DOI: 10.1254/jjp.21.361